The microbial community that lives in our large intestine is a very thick and complex ecosystem. While some of these microbes cause disease and disease (such as bacteria and viruses), others are more friendly to us and help us maintain good health.
Akkermansia Muciniphila It is one of these friendly bacteria.
The researchers have known years ago Mousinvilla It is associated with good health. One of the important roles you play in our intestine is to keep our bowel barrier function. This keeps bad errors outside, while making sure that we can still absorb the important nutrients from our diet that keeps our cells to work as it should. But when there is an imbalance Mousinvilla In the intestine, it can lead to problems with our health.
These unusual bacteria live in our large intestine and survive from Mucin – the mucus layer that covers the surface of the large intestine.
Mucin provides a small but important chapter between human cells and microbial cells that call the large intestine home. If this mucus layer is disabled, microbes can communicate directly with human cells. This may lead to inflammation where human cells interact with bacteria – which may lead to the development of the disease, such as inflammatory bowel disease.
Akkermansia Muciniphila It is very eaten. Only sugary proteins (molecules that contain protein and carbohydrates) are used in myusine as an energy source. But how these bacteria extracted energy from sugary proteins was a mystery until recently. Discover the research conducted by myself and his colleagues Mousinvilla It publishes a group of different enzymes that work together to open the sugar in Mucin.
Using Mucin taken from a pig, we analyzed both the enzyme activity on the surface of the cells along with its genes to understand any enzymes involved in breaking the sugary proteins in the Mucin down.
We discovered that Mousinvilla Use 66 different enzymes to extract the important energy it needs from sugary proteins in order to do their important job. We are the first group that describes this process.
Important for health
Studies looking at Mousinvilla Detecting interaction with the immune system in mice is that it calms the immune system and may prevent obesity and diabetes from growth.
The researchers highlighted the specific peptides (a type of molecule) that this effect on the immune system. Because of its friendly nature and the effect of calm on the immune system, Akkermansia Muciniphila Until it was used to develop probiotics.
Researchers have also found that people with metabolic disease, such as diabetes or fatty liver disease, have fewer number Akkermansia Muciniphila In their large bowels. The more poor and mathematical, the more you Mousinvilla You have.
Although Akkermansia Muciniphila Just eat mucus, our diet still affects it – although indirectly.
Colon analgesic bacteria like Mousinvilla Use the carbohydrates you extract from foods rich in fiber in our diet as fuel. On the other hand, they produce substances called short sequential fatty acids. These compounds nourish the upper layer of human cells in the colon. In fact, 10 percent of our energy comes from this process.
Bacteria live in the large intestine
Akkermansia Muciniphila It also supports other bacterial species in the microbium by giving them sterile mucus so that they can survive-a process known as “cross-feeding”. However, if we don’t eat enough fiber as part of our diet, Mucins become a great source of nutrition.
This can lead to the exhaustion of the mucus layer in the large intestine – throwing the exact ecosystem of microbium. This increases the chance of developing inflammatory diseases. So, though Akkermansia Muciniphila Not pathogens, it can remove a lot of mucus under the wrong conditions.
Our research is the first full example of how to divide mucus through these bacterial species. It is important to understand this process, because it is a key in the way our microbes interact with each other – and with us. The enzymes that we described Akkermansia Muciniphila It can now be used as tools to analyze how these complex Mucin structures vary across the different sites of the body and among people.
The more researchers Akkermansia Muciniphila And other microbes that live in the colon, whenever we understand the importance of eating a high -fiber variable diet.
Lucy Krauch is a research colleague at the Institute of Microbiology and infection, Department of Microbes, infection and Microbes, College of infection, inflammation and immunity, College of Medicine and Health at the University of Birmingham.
This article of the conversation is republished under the Creative Community Licensing. Read The original article.
